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KMID : 1130320190620090353
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Korean Journal of Pediatrics
2019 Volume.62 No. 9 p.353 ~ p.359
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Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
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Choi Yeon-U
Jeon Ha-Eun
Yang Eun-Ae
Yoon Jong-Seo
Kim Hyun-Hee
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Abstract
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Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established.
Purpose: To identify the correlation between nasal eosinophil count and EPO in children and adolescents with rhinitis.
Methods: We recruited patients <18 years of age with rhinitis for more than 2 weeks or more than 2 episodes a year whose nasal eosinophil and EPO were measured at a single allergy clinic. The eosinophil percentage was calculated by dividing the eosinophil count by the number of total cells under light microscopy at ×1,000 magnification. EPO and protein were measured from nasal secretions. We retrospectively analyzed the correlation between nasal eosinophils and protein-corrected EPO (EPO/protein) value.
Results: Of the 67 patients enrolled, 41 were male (61.2%); the mean age was 8.2±4.0 years. The median nasal eosinophil count was 1 and percentage was 1%. The median protein-corrected EPO value was 12.5 ng/μg (range, 0?31 ng/μg). There was a statistically significant correlation between eosinophil count and percentage (P<0.001). However, the eosinophil percentage and EPO did not correlate. The eosinophil count and EPO had a statistically significant correlation (P =0.01). The EPO cutoff value examined for nasal eosinophil counts of 2, 5, 10, and 20 was 17.57 ng/μg regardless of the reference count. The largest area under the curve value was obtained when the receiver operating characteristic curve was drawn using the eosinophil count of 2.
Conclusion: Nasal eosinophil count was significantly associated with protein-corrected EPO.
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KEYWORD
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Child, Rhinitis, Eosinophil, Eosinophil peroxidase
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